INTERLEUKIN 33 AND FIBROSIS: PATHOGENESIS UPDATED
نویسندگان
چکیده
منابع مشابه
Emerging role of the interleukin (IL)-33/ST2 axis in gut mucosal wound healing and fibrosis
Interleukin (IL)-33 (IL-1F11) is the newest member of the IL-1Family of cytokines and has been best characterized as a potent inducer of T helper (Th)2 immune responses. Increasing evidence, however, indicates that IL-33 also represents an important mediator of mucosal healing and epithelial restoration and repair. As such, IL-33 follows the trend of several innate-type cytokines, including mem...
متن کاملUpregulation of interleukin-33 and thymic stromal lymphopoietin levels in the lungs of idiopathic pulmonary fibrosis
BACKGROUND Innate T helper type 2 (Th2) immune responses mediated by interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been shown to play an important role in pulmonary fibrosis of animal models; however, their clinical implications remain poorly understood. METHODS TSLP, IL-25, and IL-33 concentrations were measured in bronchoalveolar lavage fluids obtained from normal...
متن کاملInterleukin-33 overexpression is associated with liver fibrosis in mice and humans
Interleukin-33 (IL-33), the most recently identified member of the IL-1 family, induces synthesis of T Helper 2 (Th2)-type cytokines via its heterodimeric ST2/IL-1RAcP receptor. Th2-type cytokines play an important role in fibrosis; thus, we investigated the role of IL-33 in liver fibrosis. IL-33, ST2 and IL-1RAcP gene expression was analysed in mouse and human normal (n= 6) and fibrotic livers...
متن کاملInterleukin-33 Prevents Apoptosis and Improves Survival
BackgroundST2 is an interleukin-1 receptor family member with membranebound (ST2L) and soluble (sST2) isoforms, and, sST2 is a biomarker for poor outcome in patients with myocardial infarction (MI). IL-33, the recently-discovered ligand for ST2, activates NF-kB and thus may regulate apoptotic cell death. We tested the hypothesis that IL-33 is cardioprotective after MI through ST2 signaling. Met...
متن کاملUpdated molecular genetics and pathogenesis of ichthiyoses.
Research into the molecular genetics and pathomechanisms of ichthyoses have advanced considerably, resulting in the identification of several causative genes and molecules underlying the disease. In 2009, the First Ichthyosis Consensus Conference was held to establish a consensus for the nomenclature and classification of inherited ichthyoses, by which an international consensus for the classif...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Medical Immunology (Russia)
سال: 2018
ISSN: 2313-741X,1563-0625
DOI: 10.15789/1563-0625-2018-4-477-484